![]() ![]() ![]() Carbapenems are currently the treatment of choice for serious infections, with fluoroquinolones being and an alternative choice, if the organism is shown to be susceptible. Multidrug resistance is increasingly seen in many Gram-negative bacteria as a result of widespread use of various antibiotics. In addition, these enzymes are inhibited by beta-lactamase inhibitors such as clavulanic acid. However, ESBLs are commonly defined as beta-lactamases that confer resistance to the penicillins first, second, and third-generation cephalosporins and monobactams by hydrolysis of these antimicrobials. There is no agreement on the exact definition of ESBLs. A major contributor to this increasing resistance is the production of inactivating enzymes, in particular Extended Spectrum Beta Lactamases (ESBLs). The widespread and inappropriate use of antibiotics has resulted in a significant increase in antibiotic resistant bacteria worldwide. Colonization of AmpC in the population of study was not related to prior antimicrobial consumption or hospitalization. Isolates among male and female university students in AAU Ekpoma. This study demonstrated a prevalence of colonization by multi-drug resistant, non-clonally-related Amp C positive E. coli isolated from stool samples healthy subjects in this axis. To our knowledge, this is the first study investigating the prevalence of AmpC-producing E. In this current study, the prevalence of Faecal carriage of AmpC genes among HCWs was 28.26%. Of the 102 faecal samples analysed, 46 were lactose fermenters which were assessed for AmpC. Faecal samples were collected from 102 students of AAU who accepted to participate in the study, who had not been recently hospitalized and had no recent exposure to antibiotics (≥ 3 months): all are from healthy individuals (students of AAU). The aim of this study was to determine faecal carriage of Amp C producing enterobactercae among students of Ambrose Alli University, Ekpoma, Edo State. In recent years, the world has seen a surge in Enterobacteriaceae resistant to broad-spectrum beta-lactam antibiotics due to the production of Extended-Spectrum Beta-Lactamases (ESBLs) or Plasmid-mediated Amp C (pAmp C) enzymes. Tel:+234 C-producing organisms can act as a hidden reservoir for ESBLs the high-level expression of the Amp C β-lactamases may mask the recognition of the ESBLs. Lassa Fever, Irrua Specialist Teaching Hospital (ISTH), Irrua, Ekpoma, Edo State, Nigeria *Corresponding Author(s): Iyevhobu Kenneth Oshiokhayamhe coli and Klebsiella Spp Iyevhobu Kenneth Oshiokhayamhe 1 *, Okelue EO 2, Babatope IO 3, Efosa KO 4, Alleh AO 5, Igbuan EA 6, Omokpo VO 7 and Oruah-Ureki O 8 1 Lassa fever, Irrua Specialist Teaching Hospital (ISTH), Irrua, Ekpoma, Edo State, Nigeria 2 Family medicine, Lakeside Medical Center, Belle Glade, United states 3 Department of medical laboratory science, Faculty of Basic Medical Sciences, Ambrose Alli University, Ekpoma, Edo State, Nigeria 4 Centre for biomedicine, Faculty of Health Sciences, University of Hull, HU6 7RX, Hull, United kingdom 5 Department of public health, Derby University, Kedleston Road, Derby, United kingdom 6 Microbiology laboratory department, University Hospital of Leicester, United kingdom 7 Department of biological sciences, School of Applied Science, Auchi Polytechnic Auchi, Edo State, Nigeria 8 Federal neuropsychiatric hospital, Benin City, Edo State, Nigeria ![]()
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